Humane Endpoints for Genetically Engineered Animal Models

Humane endpoints for infectious disease animal models.

Since the work of pioneers such as Jenner and Pasteur (Fenner et al. 1997) more than a century ago, animal models have provided essential information in the study of infectious diseases. Although much experimentation can now be accomplished with in vitro systems, animals continue to be necessary for this field for studying the process of inflammation, specific infectious diseases, and pharmacol...

Pain management and humane endpoints.

The International Conference on the use of humane endpoints in animal experiments for biomedical research.

Proceedings of the International CO'1ference, 22-25 November 1998, Zeist, The Netherlands. Coenraad F. M. Hendrikson and David B. Morton (eds.). London: The Royal Society of Medicine Press limited, /SBN /-85315-429-6. Zu beziehen bei den Herausgebern. Nachdem wir mit unserem heutigen Wissensstand noch lange nicht in der Lage sind, aile Tierversuche zu ersetzen, ist es fur das Wohl der Tiere una...

Genetically engineered, live attenuated vaccines for Venezuelan equine encephalitis: testing in animal models.

The central objective of this research was to test molecularly defined, live attenuated Venezuelan equine encephalitis virus (VEEV) vaccine candidates that were produced through precise genetic manipulation of rationally selected viral nucleotide sequences. Molecular clones of vaccine candidates were constructed by inserting either three independently attenuating mutations or a PE2 cleavage-sig...

Humane Slaughter of Animal

The campaign against butchery by cutting the throat, while the animal is conscious, has been renewed recently with the gratifying effect that newer methods, more humane in nature, have been devised. The German Society for the Protection of Animals in 1927 and the International Congress for the Protection of Animals held at Vienna decided against the procedure of ' butchery without concussion Ma...